Chesdina, I'm sorry. I hope you found the video useful. An audience of 13 is great. Often when visiting and giving a seminar, 13 would be considered a good number. Thank you very much. Just a thank you as well.

So, let's get on with this talk and the title today is Neural Transfection by COVID-19, Potential Behavioural Sequelae. Sequelae just means follow on symptoms that occur after the initial trauma or disease onset. Excuse me. Now, for a small group of friends and family, I made a video a few days ago after I'd seen a paper come out last week in the journal of medical virology, which basically talks about the capacity of SARS-like agents to transfect from the body into the peripheral nervous system and from the peripheral nervous system into the brain. Now, this is, I might pop the odd joke or two and it's not going to be as fun as the normal streams of people that know me, but because I'm basically coming out of cover here. I'm putting my name to this. I'm basically going for a call out of the World Health Organization, the CDC, the Surgeon General of the USA. Who else could I think to laze at this particular moment?

Well, and literally most governments across the world have been caught literally with their pants down and are now scrambling to redress the issue of the agent that potentially came from a Wuhan BSL-4 facility that would be research into biological weapons. So introductions aside, that's me. My contact is on there. If you want to talk at any time, please tweet this out right now and let's try and get this information out to as many people as possible.

There are many slides. This will be long. So please just settle yourself in and if something you don't quite understand, I can try and capture the comments and I'll see if I can sort of break and sort of expand from there. But let's try and do the majority of the questioning at the end because there is a lot to get through. So first problem as always. I want my laser pointer please. Come on. Okay, great. So let's move on. Change. So repeatedly the authorities, those who are supposed to be taking the roles in society for your well-being, looking out for the health of a country, have repeatedly come out since the breakout in China and have said masks are not useful, obligatory, potentially not useful. And as of today, the Surgeon General has said the risk is low for Americans. There's no need to wear them. And same with the World Health Organization, etc., etc. And I think from the entire time that this thing started, I was watching it very early. The response, hang on, I'm just responding to another. I have to take this one. It has some echo. Is the sound okay? Okay, I'm looking in the YouTube chat. I'm getting complaints of some echo. Do we have echo? Thumbs up, thumbs down, anything? I'm presuming it's going to be okay. Let me do something. Slight echo. Is it better now? Okay, small echo. Let's just move along. A little thing like echo shouldn't get in the way of this. I think this is very time-sensitive information and we will... Little echo, little echo. Well, I just tried adjusting the mic. If I keep seeing little echo, tiny, cheers, slight echo still. Hang on, I will... I apologize for this because we're already getting behind this. I'm presuming this is going to be...

That just knocked us right off the scale. Okay, so I'm hoping this is better. I don't have to shout and we can go from there because the data that I want to show you is time-sensitive. It's going to go very deep, this talk. You don't have to pay attention all the way through. I know it's going to be long, but I want to get a piece together and then we can cut it up and edit it up afterwards. Let's just move on. I'm saying that these organizations have gone basically from negligence. They've stepped into the realm of malfeasance. I'm very skeptical of how they've gone around trying to deal with the outbreak. In that context, let's move on. I'm going to quickly cover the basics around COVID and the infection.

The first question anyone with any sense of... Am I straining credulity? The first thing would be, why is a systems neuroscientist talking about COVID? Well, I have training with respect to using BSL state facilities. My initial feeling was that the protocols for BSL-4 were not being adhered to properly in terms of fallback and containment. The Chinese did wind it up pretty quickly, but I don't think the same is going to be able to be done in the West. The statistics coming out of China were very obviously just bad data. You could just see that the R value for the slopes was too good and the data actually just not being random enough and them changing the classification for how they want to diagnose, which all governments seem to have done as they sort of scrambled to get a grip. It was one of the primary reasons where I really started to think about, well, do I come out publicly and say something?

That's when in the middle of the Chinese outbreak, the World Health Organization just literally turned around and said, well, we don't have the criteria in place anymore or the resources in place anymore for something like a pandemic. This to me was peak absurdity and a theater of the surreal to hear these people saying it with a serious look on their faces, wanting you to trust them with your safety and instructions on how to lead your lives under such conditions. It was very obvious that the dollar was more important than lives and safety and that to me was disappointing. I had issues with what I thought were breaches in BSL-4 and what was curious to me was you could make the argument that you see these kind of behaviors everywhere, but this correlation of what I would consider abnormal or bizarre behaviors that seem to be being associated with the infection. As a systems neuroscientist, that caught my attention and one of the things that I specialize in is the region of the brain, a bunch of networks called the limbic system. It forms part of the cordicobasal ganglia cerebellar networks.

It's huge. It's basically at every level of your cerebrum, so above the spinal cord, is what I've been trying to study as it relates to movement disorders and a treatment called deep brain stimulation. Now that's all well and good and I could just sort of sit in the background just kind of watching what was going on. I had pulled my kids out of school early because I was that concerned with what I was seeing back in January. This is highly abnormal for Japan, but we decided to take that step. I would encourage all parents to do the same if you possibly can. Work from home if you possibly can and try not to worry about the money so much right now. Okay, money is important of course. I would like a little bit with everyone, but don't go all out for it would be my take home point and I'm digressing, so I want to keep on target.

What are these abnormal behaviors? Here's an example of some of the bizarre behaviors which is, I just pulled this off the internet, so whoever Jeff channel news is, thank you for just sort of aggregating this and keeping up there. What you're going to see is just a man come in, spit and wipe his handle over the touch panel. A similar response coming in with almost what looks like a family or they're all related or they all know each other. You're going to see him, but he presses the, or she presses the button and then suddenly this guy just starts wiping it all over. I can't even tell if she, if anyone's paying attention or like I said, it's a very confusing bit of footage and then they sort of go off the same way. So I'll leave the tag in for whoever this was. Jeff channel, thank you very much for putting that up. The other one is from China, morning news, maybe something like that. And basically this is a young man who got highly agitated after being reminded to put on his mask. Now there's, you know, you're going to get some salty language in this presentation. The man is obviously an ass and where this be, you know, maybe he is just a violent offender, but this looks like a very classic loss of inhibition and your brain is set up. And even, even the girlfriend comes in, has a go. And you know, if one one's infected, the other is too. And here you can see the man being detained and the man detaining him in full PPE, right? So a lot of this talk is about my objection to what the authorities have told people in the US in Europe about masks and PPE. I will show you that you absolutely have to. So there's the attributes for those videos I've tried to go through this and give all the attributes where I, where I knew they were missing. So please, if I've missed anyone, please bear with me. This is another example.

I don't know. You know what? We've seen one. It's no need to dwell. We can. There's more of this behavior. You just have to keep looking. Knife fights for something as bizarre as toilet paper. And the, well, like I say, behavioral instabilities that people are showing that are going to be compounded by virus, sorry, panic buying as a consequence of the COVID infection. And, you know, what I would like to do is everyone to just try and sort of remain as calm as possible. Keep your social distance at a maximum, all these kinds of things. And I don't want this to be like a fear mongering video. It's intended for you to understand the nature of what we're dealing with. And it's not just a flu gave that much we know. And once we can transfect the nervous system and the virus can jump once it's in the nervous system across synapses, then you're dealing with a very, very different type of beast. And one disease which we know has that property is rabies. Now I'm not saying COVID-19 is rabies, but if it has this ability to jump from synapse to synapse, the results could be unpredictable, as we don't know how that's going to pan out on a large scale population.

So we're talking billions, billions of people here. So that's why a neuroscientist is talking about COVID and COVID-19. And this is the publication that I was talking about. It came out last week, Journal of Medical Virology, the title hopefully by now makes should make some sense to you. The neuroinvasive potential of SARS-CoV-2 may be at least partially responsible for the respiratory failure of COVID-19 patients. Yanchao Li, Wang Zhu Bai, Tsutomu Hashikawa, I'll be honest, okay, and we all have to be careful about our biases. I have one particularly. It just stems from reviewing a lot of papers that come from China. They do publish a lot of science and often they lack credibility and the authors, if you look where they're from, the middle one is from an acupuncture school. And the reason I took note of it is Hashikawa, the last author is affiliated with the RIKEN Brain Science Institute {now the RIKEN Center for Brain Science}, an institute that I'm affiliated with and done many of my publications with. So I'm somewhat confident in the quality control within the institute. So quick first point, this article states that masks should be a priority. And if it's a priority for one, it's a priority for all would be my line of argumentation. The next slide is just a couple of bits of text that I've extracted from the paper that I thought were of particular interest. If people want the annotated version like this, I can send it to them. You can find the link and I don't think I put it in the description box. I was in such a rush to get this put together. But let's just read the first word because this is telling. According to the complaints of a survivor, the medical graduate student, 24 years old from Wuhan University, so she's from the city of the outbreak, reported she must stay awake and breathe consciously and actively during her intensive care period. So think about what that means. Normally your breathing and respiration is subsumed to lower down networks in the medulla and it's actually sort of sits below the brain. And that takes care of most things for you. So if you run after the bus and get a bit out of breath, that will sort of try to kick in and sort of keep your blood oxygen at a level that you're not going into sort of acidosis or something like that. Then towards the end of the paper, it says if SARS has similar features like COVID-19 and respiratory failure. So this is the bit I've highlighted. Precaution with masks will absolutely be the most effective measure to protect against the possible entry of the virus into the CNS. It may also be expected that the symptoms of the patients infected via fecal, oral or conjunctival route will be lighter than those infected intranasally by virions, viral particles coming into your nose and into your sinus cavities. So let's move on. We're going to get a bit of neuroscience here and you're going to get a look deep into my soul. And this I'm using a MRI of me to help illustrate something. So let me just get on our pointer. Let me try and orientate everyone. So this is my eye. You can see and nose obviously. And that's the pupil, the dark spot there. And this is the optic nerve going back in to the optic tract. And here underneath the eye is the olfactory bulb.

And this is a weak entry point into the central nervous system because once it's jumped in here or it begins to transfect here, it's then one synapse away from sort of higher order areas, particularly in the limbic system, as we'll find out, but also projecting down, like I say, the consequences of it transfecting and jumping synaptically in sort of modeling studies. Basically, you can go from everywhere to everywhere in a minimum of three synapses in the brain. I know that sounds kind of weird, but maybe that will sort of come out as I do the more technical side of this talk. So the... Oh, I've lost my chat. That's unfortunate. Chesina, you're more than welcome to a copy. I've got my email up. You can just email me. Let's say I'm easy to get a hold of. Basically semi-retired, as I said earlier, from a head injury. I know that there is a certain irony to that. I have to give a little chuckle. The good Lord works in mysterious ways. And the point being that from the olfactory bulb into the brain is a short jump. And once you jump synapses, the consequences potentially could be dire.

And… I have YouTube on. I can't see the next slide coming.

So in the next slide, you're going to see a schematic of a primate brain. It's slightly different. I mean, you'll see the similarities in structure. So let's just go to that quickly. So this is the lateral view. In this particular one, the eyes are where my pointer is. These are the optic tracts. And this is if you did a transverse slice. No, not transverse. Never mind. It's not important. If you slice through the brain. So still side on. So you probably edge of the eyeball here. And what we're interested in is this area here, which is called the nucleus accumbens, because I think this region and its potential transfection by viral particles could be accounting for these more bizarre behaviors. And I'm saying it's going to happen to everyone. I'm going to preface all this with I'm not a medical doctor. I'm a research scientist. I often work with medical doctors, surgeons in particular. Like I say, I'm not giving you medical advice. I'm trying to give you knowledge that will help help you understand what's going on, hopefully keep you out of harm's way. And hopefully you don't panic because you think you don't have a mask or something. So what I want to do is try to ease those tensions for you. A bit of a bit of neuroscience psychotherapy from Dr. McCairn. So what do we have below this? Well, there's a title of this slide is, and I'm using the the web meme Corona Chan, because I'm so disappointed with the World Health Organization and how they've acted. I don't think their nomenclature for the for the virus is you could just disregard it as much as you could disregard much of their advice as far as I'm concerned. And there's a much more humorous and good descriptor of the agent that's a meme on the internet where it's called Corona Chan. And this was coined by the weatherman Jim Metica. So hat tip to him. And I might swap interchangeably between Corona Chan and COVID. And what this says is once it's so it can affect the central nervous system in a multiple ways and pathways. And when you've done that, the in the brainstem, there's an area called the Botzinger complex. And that's what's represented in this slide. So this is a ventral respiratory group. Botzinger is usually around here. This is the cranial nerve seven. And these are what's called electrophysiological recordings. And you're going to see a bunch of this in the more technical aspect of the talk. But let's let's look at what happens here. So with this mouse pointer here, you've just finished breathing, there's a pause in your breathing, they fire spontaneously by themselves. And then they they ramp up and with it your breathing will so go down pause like that. And it's doing it all the time, all 24 hours a day, 365 days a year, this complex is interacting with your pulmonary system. And this little diagram was taken from quite a old paper, but that to me that doesn't seem old, because that's when I sort of started my career. And but it is 1999. That's pre 21st century. Last century is data that we're using to illustrate a 21st century bioweapon. How about that for meta? So so Corona Chan, that little devil princess will come in, she she can infect the the innovation to the intercostal muscles and the diaphragm that comes from like the phrenic nerve and forms part of the parasympathetic and sympathetic branches of the center of the peripheral nervous system, it latches on into there, it climbs up the spinal cord, gets into this region here causes cell death. And basically, if you don't get intubation at this point, which requires nurses, anesthesiologists, someone to get the tube in, you know, it's a complex procedure, and then you need to be on ventilators. Okay, do they think you're they think you're somewhat better. So that's so we'll say a priori that Corona Chan COVID, whatever you want to call it, like the other SARS variants can destroy this area. And this new paper is saying to pay attention to the the olfactory route, because this olfactory route has this potential to get really deep into the brain. And that's what we'll be exploring. So moving on. So this is my brain again, this is this is the transverse section. And the other one was a parasagittal section. That's the word I was looking for. So transverse means the sort of sliced my head like this sort of sideways. So basically, it's looking down. It's looking down through the top of my head. And the potential to synoptically jump to nucleus accumbens twice. Nevermind. And here's the arrow pointing it this is part of a larger complex called the striatum. And the striatum, along with some region called the globus pallidus and a few other nuclei, these form a structure called the basal ganglia. And these structures have a lot to do with behavioral initiation and suppression, suppression of unwanted access action. So it wants to pick the right action, and then disregard all the rest. So I could say, like, my own look at myself looking at my desk, oh, I want to I see my mints, I want to pick my mints up. Now, my ballistic trajectory to sort of reach out and take it is straight to the mints. But in order to do that, I have to suppress all the other lines or vectors it could go through to to get that to get my mints quickly, put it that way. And again, I get more into depth of what the basal ganglia are doing as we progress deeper into this talk.

So this is the meme from internet Corona Chan. But Corona Chan has the little the little minks already mutated to give us a twin. And that too comes from the Journal of Medical Virology. This, again, just to reiterate, I'm not a virologist. I'm not a medical doctor. I'm just looking at this data, like, I trust the ganglia ganglia. That's a good one, Bruce. Thank you. So I don't want to go into their realm and talk about the ifs, whys and nots of if there's a mutation. Apparently, there are the SNL variants. I just want to be able to look at that and say, well, how does it apply to my discipline? How does it cross transfer? So I need to think that there are two different variants now. And so do you.

So keep that in mind. So where did I did I was I scouring the the NIH databases to find that? No, actually, I got it off of information feed from I don't even know what this Cree. I can't remember. Search for Tyler Durden. Scientists discover more aggressive strain of coronavirus. He's the chap that did this. And this is the graphic they put in. And that's why I use this graphic, because it's quite it's quite a good summary. So the S, right? is 30% of patients. It's the original strain of the virus, less aggressive and slower spreading causes milder illness continues to infect new patients at a steady rate. The L type, which is 70% of patients mutated from S strain, more aggressive, faster spreading causes worse illness. Excuse me, most common in early April outbreak outbreak in Wuhan, infections have trailed off as outbreak has spread. I'm not sure that's the case, because I've been seeing reports today of China reporting secondary outbreaks. This thing is not over, not by a long shot. And that's why those in authority requisitioning all the PPE for themselves,

I think is incorrigible. And yeah, you know, it sort of makes sense from a civil defense aspect. But if the people feel themselves threatened, because there's not a there's not a supply getting out, then you know, someone, someone has to step in and do something. So yeah, we've established that there's two isoforms, two, yeah, isoforms of woo flu, COVID, Corona Chan, here's the here's the two little mutations or the original and the mutation. So we let's move on.

So the same people who are telling you not to wear masks are the same people that were telling you a few weeks ago that it doesn't infect your pets. But now, in South China, they're reporting that it's affecting pets. And I saw on some discord, where did you download the PDF? I will I will put a link in the in the chat. Let me see if I can do that. Bruce, do you mind if I just give it to you? The at the end of this talk, because it's sort of breaks a little bit of the flow. I don't mind the question for that. But you can. I'll put all the information in and sort of go from there. So I apologize, Bruce, I can't sort of multitask as much as some of these youngins do today with their phones.

Let me get through this, because there's a long way to go. Okay, so pets, pets, pets are potential hosts, and reservoirs now. And Corona Chan appears much more lethal than originally thought. In the US, it was showing 7% mortality rate. And yeah, that's high. If you think flu is like 0.1%, that's orders of magnitude worse. And even let's just low ball it. And I think sort of 3% is on the lower end of what people are reporting. Even 3% at a medical level, you know, 100,000 people have just been infected. That's 3000 people dead. Okay, and so on and so forth is that slope accelerates upwards. And I have to apologize for lack of accreditation on this one. I can't I can't remember exactly where I pulled this from. So if someone recognizes it as theirs, and want me to put a citation in, I will and I just couldn't find it in the time to get this presentation up. So apologies, my bad.

So potential for severe societal instability. Now, in Japan today, a video emerged. This was March 2. The video has been taken down. You know, Japan has its ways to and Japan is trying everything it can to make sure that the Olympics goes ahead. And it's dollars baby that they want. They don't care about the people. They don't care about the drones who are just making taxes for them. But in the video, this guy standing up loses his call on the main line, the circular line around Tokyo, the Yamanote line. And this is a this is a train that's usually packed virtually all through the day. And you know, one of my big complaints and it's in the other video is the Japanese government were prepared to shut down major parts of Tokyo to allow for a marathon to take place. Because presumably, it's linked to the it's linked to the Olympics. But they still hadn't done anything with respect to closing schools. And in my mind, that just really excuse the French, but boils, it really boils my piss that these people would think this way that it's it will take the financial here for the for the potential of a better financial hit for the summer Olympics, and then not care about the schools. I mean, my kids were out, but I just couldn't believe that with, you know, Japan, even though much is on the ship had over 1000 cases, and I have my suspicions about Japanese reporting much like I do the Chinese because yeah, this is this sort of high conformity, a bit a bit totalitarian, if you like. And of course, Japan is much more westernized. Many of the people that I meet here are really great. The bureaucracy sometimes just leaves me slack Jordan in often despair. So and then the who at the same time this was well within 24 hours of each other is telling people is policing people's language, the same people acquire or contract, don't tell people are transmitting, don't tell people are infecting or spreading the virus, as it implies intentional transmission and the science blank brain. Now this to me is again the height of absurdity where an organization knows the importance of masks, and is telling it's the it's telling the people who are looking to towards it for some sort of guidance. You worry more about your racism and your bigotry than acquiring what's potentially deadly pathogen. And it's just such a time sign of the times that to me, yeah, like I say, a lot of this, you know, it's accelerating more rapidly by the day. And the like I say, the organizations are negligent and straying well into malfeasance. So that a few times and I'm going to keep repeating it. Sorry, this gag is in the first presentation I did and about the use of PPE, protective clothing.

And it turns out that Islam is right again about COVID-19. Those little naughty Corona chans should be in a burqa. And because they're not these good muslims are and that some they're lacking the gloves and the chemical goggles. Oh, no, some some have gloves. But I'm pretty sure chemical goggles were not a thing back when they were Mohammed peace be upon him wrote the Quran. But for one of a better solution. Yeah, there you go. There's an easy one. Don't think you have to have n 95 masks or whatever you just the take home of this talk is you just need to limit transfection via the nasal mucosa. That's the take home point of this beginning section. So Corona Chan, the wicked little witch is ratcheting up global tensions.

So back in February, a Chinese scientist finds killer coronavirus probably originated from a laboratory in Wuhan, UNC. I'm not sure I read that article, but University of North Carolina maybe researchers possibly involved. And the thing is, the the leadership of Iran have abnormally abnormally high degree of infection, which makes me you know, a lot of the channel when I started it was, well, is this some sort of acts I wanted to sort of interact with people with the idea about is this a biological weapon? And is it an attack? And, you know, that's very, very difficult to say. But the fact that Iranian leadership has taken such a big, big hit. The the fallout could be severe. And, you know, the Iranian higher ups are the they believe in the 12th Imam, the 12th sect. So they they honestly believe in like an end time scenario, where the Mahdi will come out of a well in riding with Jesus Christ and break all the idols. So everyone worships the one true God Allah inshallah. So more ratcheting up the tension. So on the 4th of March, virus is biological attack on China and Iran, Iranian civil defense chief claims. So this again is indicator of how severe this is any country accusing anyone of chemical biological attacks. It has a very good case for Cassis Belli. And the I would imagine the Iranian leadership are feeling pretty angry right now, and they're going to be looking for some some form of retribution.

So excuse me. So we need to be careful. And that's why I think, you know, if we can just ratchet down everything and get everyone onto a more sort of stable and calm basis, hopefully everyone can sort of sort everything out. The same is occurring in the other little hotspot in the Middle East. So IDF holds major air defense drill with us as Coronavirus restrictions intensify IDF chief calls off us visit out of Coronavirus fears. Okay, so it's not just one country getting involved. The military in many countries seems to be getting involved. And just okay today. Yeah, it's probably the burqas sound better than shorts for this summer. Yeah, it's it's going to be the fashion pick that much I'm sure of. No one's going to go be wanting to go out with their flesh there for all to see, both male and female. So let's move on.

So this is more examples of the ratcheting up. So this is not really to do with the current… well it is because it's trouble in the Middle East, but Russia and Turkey are starting to come to blows. Iran in light of the outbreak has ordered the movement of 300,000 troops and volunteers. So troop movements, massive troop movements are ongoing. And like I say, quite concerning. And I guess I'm getting towards the end of this sort of where I've been speaking to people about the virus and the sort of social things and whatnot.

But as things progress through the time period or the period that this event has been ongoing, there was a study, not study so much, but a claim made by Chinese doctors trying to treat the condition that chloroquine derivative of quinine is a potential, not cure, but it seemed to help with the symptoms. And to the right of that, people are looking to appropriate this active molecule quinine. So that this is it for any chemistry people out there. They want to try to use it in this case from dengue virus. And if you don't have access to anti-malarials and quinine, the one thing I could think of is real tonic water has quinine in it. It sort of provides the bitter taste. And I think there's good causes. Everyone soon going to be shut in their house. You can have a few gin and tonics. Just make sure your tonic, when you put it under fluorescent light, glows like the Canada dry bottle in the image below. So quickly moving on, just some of the largest social impacts. This is a long video. I'm not going to play it. But the image to the right here, what you're looking at is the central mosque where people go to the Kaaba and they circle around the Kaaba in the grand mosque in Saudi Arabia. And that's what people do during Ramadan, the Hajj pilgrimage. And they circle around this thing and they do it by the tens of thousands. And there's always people doing it. There's live feeds from Mecca. And pretty much at any time of the day, people are circling this black cube. And this aerial shot just gives you an idea of all those little dots. They're all people. But if we move on, so we've got a close up now of the black cube. So you can see the black cube here. And this is as it is right now. So virtually empty. I can't think of anything that has even come close to this.

The only sort of world consciousness changing event that I would even put it on par with is 9-11. So Nick Laws just wants to ask, my question is, what if any connection is there between Dr. He, Jankyu and Wuhan, if any? I'm not sure. You'd have to expand on who he is. He seems, it almost sounds like a Korean name. But I don't know. If you could just, I don't know who he is right now. The name's not ringing a bell. My attention is focused on this. I'm happy to do some Googling at the end and we can all chat and work things out. But there's many, many more slides to go because we still haven't got to anywhere approaching the neuroscience that I want to cover. So there seem to be some good news on the home front. And Dr. Stunder's coronavirus leaves children virtually untouched. And as a parent myself of three young children, I'm absolutely thrilled if that would be the case. However, a more recent report from University of Minnesota is revealing a sharp increase in COVID-19 in kids in Shenzhen. Now, if this is a consequence of reinfection, I don't know.

But this is very concerning. So this needs a constant eye on. My advice has been, if you can keep your kids home, if you can work from home, isolate yourself as much as possible for the next 30 to 60 days would be my advice. The world needs a break for 30 to 60 days. And those people that are just pushing for their extra digit on their pensions or bonuses just need to sit down for a change and let the adults do some talking and let us get this thing under control. So moving on. I forgot to change this. So ignore the title.

So basically, this is supposed to be titled Now Comes the Neuroscience. So we're looking at my brain again, and we're going to look into the brain. And essentially, we're going to talk about corticose. So corticose is this cortical layer around the outside and basal ganglia. And the basal ganglia basically just fill all this region here, all underneath. And there are a bunch of highly interconnected, very complex networks that help you select behaviors, wanted behaviors, and suppress others.

Yeah, anything covering your face is better than nothing. You'll sort of see in my, and I kind of, maybe I cut them out just for brevity's sake. So this, I'm going to skip through this first part, because this is the sort of introductory component to a lot of lectures that I give. It's how we know what we know. And it's because of those cortico-basal ganglia. And also, I'll just scroll up this region here, which is called the cerebellum. Excuse me. So, and a little interesting factoid. This is derived from Harami Natal. He's a bit of a free thinker and a rogue himself, but it is published work. He's done it with a recognized physicist. They basically do the same thing with mass. I'm less comfortable with mass. I like distance, thinking cosmologically, because I'm not sure we really fully understand what mass is yet. And but human beings sit at this sweet spot. If you take a logarithmic scale of space, distance, versus the logarithmic scale of time, and we sit right in the middle of this distribution, going right down to the subatomic and right up to the largest, which is the known universe. So quick, I'm going to blast through the rest of this pretty quick. If anyone's interested, get in touch with me. But 99% of all that we see in that space is plasma. Everything is positive and negative charge. And I have the, I use the vernacular. So this is mine. I've coined it. No one else is to take it. That organism should be defined as a biologically stabilized cold plasma. And I'm prepared to get into all the plasma physics of it with you, but that's not what we're trying to achieve here today. We're trying to understand how Corona channel COVID induces what was jokingly put in my first video, the zombie apocalypse. So let's move on.

So your body has complex electric fields around it. My brain body can be considered a complex tensor manifold. Don't worry about this. It's not important. Phase amplitude coupling of electric of these electrical signals are important for the integration of those things, mind, brain, body, soul. And there are different ways of looking at systems. There's Western ideation, reductive identification of causal mechanisms. Eastern ideation tends to be more concerned with whole, gestalt or holistic views of organisms, less concerned with minutia and causal mechanisms, because often in complex systems, it's very difficult to actually pin those down. There's always some ambiguity. The classic example being quantum mechanics. And we can move on from there. Now, hopefully I'm going to keep quiet, but you're what you're seeing on the screen of what you're watching right now is the spectrum of the boundary conditions of the healthy individual and how when those networks cross a boundary and go into the hyperkinetic state, you get things like Tourette syndrome, motor tics, vocal tics, neuropsychiatric disorders, OCD, ADHD. And I'm going to let this video play. And you'll hear the woman, the young girl have a tic.

Okay, that video has stopped now, but I hope you heard a tic. And you could see the difference between the healthy individual, the person with tics and OCD and someone with Parkinson's. And most people can very clearly differentiate the healthy behavior from the abnormal behavior. So this is what I want to tie into and focus on with this talk. And particularly the neuropsychiatric disorders, OCD and ADHD.

Okay, so everything stopped. We're going to go to the next slide. Come on you. Oh, yeah, we can skip that slide failure. Okay, doesn't matter.

So what we're getting into now is the more sort of hardcore theoretical descriptions of so cortex, all these nuclei are basal ganglia. And there are a whole bunch of pathways that interact with like a sort of push pull of excitation and inhibition and the sorry, if I hear myself in the headphones, it's quite distracting. So I just had to turn that down. But basically, the theoretical foundation for understanding that spectrum of Justina, don't worry about the mask. It's not critical. And right now you'd be doing more harm by putting yourself in and around potential carriers. That would be my advice to you. Okay. And the panic will die down, you will get your mask if you need them. And right now, you know, a scarf, a light scarf, silk scarf, anything like that. If you really want to sort of venture out and get something. Don't panic about the lack of these masks. Okay, they've been requisitioned by the authorities. They don't care about you. They want the masks for essential personnel from nurses, the doctors, to administrators, to the soldiers who are going to be maintaining the order because the police probably won't. Anyway, I'm digressing. And we need to talk about these pathways and how they relate to the hyperkinetic neuropsychiatric disorders. Specifically, I'm going to try and just leave Parkinson's out of this talk. Okay. Now, all this can look very confusing, especially when you have to try and understand the waveforms and patterns of activity as they line up and interact across extended networks. And you get lots of anatomy that can look really disconcerting and a lot of it. And you could literally spend, well, you do spend your undergraduate and postgraduate just trying to get your head around what these mean and enough experience to manipulate them in a way that becomes experimentally useful. And I'll add it in an ethical brain work. So, fortunately, we can do away with most of that nomenclature. And we just need to know this nucleus in the brain. This is the output nucleus of the basal ganglia. So, information feeds in from the cortex. It goes into this area called the striatum, which is usually quiescent. The cortex excites activity here. That progresses through the palatal complexes, the subthalamic nucleus.

But the key factor is that this unit or this nucleus has a very high spontaneous firing rate. When the high highest in the brain, typically about anywhere from 70 to 100 hertz or spikes per second, the neuron will fire. And it's doing that your whole life. And it's quite astonishing when you think about it. But like I say, I might be losing some of you because of the technical jargon. I don't want to do that. All you need to know is this is generally inhibitory onto the thalamus. When you want to do a movement, that inhibition increases. It disinhibits. So, that means the thalamus gets more excitatory. And then that reinforces the action in the cortex. The cortex wants to do something that sends the command down to these subcortical structures. It's processed. The GPi disinhibits the thalamus back around to the cortex. And disinhibition, so the reduction of GABA, the inhibitory neurotransmitter, is sort of lessened. And the pathway sort of process that very quickly. And they allow you to have sort of semi-automatic control of behavior, conscious control of action. Like I say, people have been, some of the best minds in the world have been trying to figure out how these nuclei interact. And I'm not saying I'm one of the best minds in the world. I might have just struck out and got lucky with some data that I was able to collect. And we'll go through that data. Oh, so this is some of the deep brain stimulation. This relates to Parkinson's disease. It's not important. But if anyone listening wants to talk to me about Parkinson's or deep brain stimulation, I'm happy to do it after this talk. So, let's move on from that slide. Let's get back into more of the basic neuroanatomy. So, these areas colored yellow on the cortex are basically part of the skeletal, sensory skeletomuscular system. So, anything to do like controlling your arms, hands, and ocular motor function. You want to actively look and hold your gaze on something or I gaze at you guys on the camera. Okay. Then there's the green executive functions, which is part of the dorsolateral prefrontal cortex. And the blue is the limbic regions, which is the part that I specifically want to focus on in this talk. And the limbic system also includes actually, we can go back, maybe my MRI might be useful here. Let's just get back. Maybe. Kind of. So, around here are areas called the anterior cingulate because there's a bunch of fibers under here. And like I say, this, I don't want to lose people in the technical jargon. But so, this round here is orbitofrontal. That's limbic. And so, is this region here of cortical regions, which forms part of the anterior cingulate. So, let's get back to where we were. Skip, skip, skip. Thank you. Thank you. Thank you. So, this is just a line diagram of how the original networks were thought to interact. So, looking at the cortical mantle, the striatum and basal ganglia. So, all this around here is the basal ganglia. And the basal ganglia, through this pathway, through the thalamus, two cortex, it was originally thought that any cross communication. So, on one side, you'll have the cortex basal ganglia, but the cerebellum on the other hemisphere communicates with the left side. So, you've got like this twist or it's called a decussation of fibers as they go down. So, the left hand side of, the left hand side of your brain controls the right, vice versa. And it's the same for the cerebellum. So, but don't get too bogged down in these figures, but historically, most people thought any interaction between the cerebellum and the basal ganglia took place at the level of the cerebral cortex with the onset of viral vector neuronal track tracing. So, this ability to jump through synapses. Researchers were able to show, these are the original works, if people want to follow these up, showed that the striatum and the cerebellum actually communicate subcortically as well as potentially at the cerebral cortex. And this is literally a game changer because the synaptic distance between the output of the basal ganglia to the thalamus and the cortex and to the output of the cerebellum, in terms of synapses, it's the same. It's two synapses away. And that's critical for trying to sort of understand the order in which someone wants to plan out a behaviour. Excuse me. It's a tough job talking people, especially, especially I've been doing it all day. And I obsessively and compulsively suck mints as well. So there's a little OCD from Dr. McCann. But I don't smoke. So that's, that's my substitute.

So you're going to get a trigger warning now. So you're going to see a lot of animal experimentation and you're going to see how your sausage is made. Okay? Now some people might find this highly disturbing, but I'm thinking things are moving so fast. Being forewarned is forearmed and the, the animal figures are going to shock people and the behaviour, but you need to see the behaviour in context. So you can understand what potentially could be the reason for what we looked at as this abnormal behaviour in, in Japan, not Japan, sorry, China. Yeah, it's getting late, but basically what you're looking at here, these are our towers that are put on. So this is an acrylic implant that's put on top of the skull. It allows access into the brain. So here it's targeting the cortico-basal ganglia structures on one hemisphere. And this one, it's targeting the cerebellum on the other hemisphere towards more of the back of the brain. And like I say, if, if you're upset by seeing animals being experimented on now would be the time, if you're watching this at a later date to slip, to skip through, I guess for what, if you don't need that information, I'll sum it up at the end. But for those that are interested to learn, this is what I show students in lectures and what I show medical professionals. And I think it's a case of, in my mind, it's a case of we've got to, we've got to stop acting as gatekeepers for knowledge or stuff and holding people to account for systems that have got us into this mess in the first place. And that's just good old corruption, money, power, influence. All these people are highly motivated by these factors.

And yeah, we need some way to sort of unwind that and reorganize stuff. So science is done objectively and doing science objectively and transparently as transparently as possible is what I'm going to show you now that this accounts for the videos that you're now going to watch in a few minutes. So how do we disinhibit these targets in the brain? So we've got sort of sub-millimeter accuracy once we've sort of done all the preparation. And in order to get a network to respond in a way that models a pathology that we're interested in studying, we have to disinhibit an area and we use a drug called bicuculine. And it's a GABA antagonist. And essentially one microliter drop is placed into the target region. One to five microliters usually is enough to get the effect that we want. That kicks in very quickly the change from a normal state to a pathological state. We can then watch the behaviors unfold and record the neural activity in real time and correlate each with each. And that helps us inform ourselves with respect to therapies and in my particular case, deep brain stimulation. But also let's hope it's providing some insight into COVID for some people. That's the thrust of why I'm doing this. I'm going to get all hell from all my peers for showing you what I'm about to show you. So in order to get the sub-millimeter accuracy, what you're looking at is a fusion MRI CT combination. And we can look in vivo where our probes are going prior to experiment with planning and also afterwards. And in this case, I don't know if I can stop. Oh, no, it didn't stop. But I want to just, it doesn't matter. The neuroanatomy with respect to neuroanatomy, you're going to be fed up of hearing the words nucleus accumbens by the end of this. Okay. So when I first started my doctoral degree, I was in the, I started in Paris at the Hopital Saint-Petriere and was the home of one Gilles de la Tourette, the person who first defined Tourette's as a recognizable clinical pathology. And Tourette's has been a strong theme obviously at that hospital ever since. And so that was what I got inducted into the modeling of Tourette's and the skills and techniques in order to be able to reproduce the same effect again and again. That's what science is. You do something, you repeat it hundreds of times to give yourself statistical power to say something about, something sensible about the phenomenon that you're discovering. So if people want to follow my studies, this is earlier work, let's say 2004. I will put a link into my research gate profile. You can go read all these papers in depth if you want. But the take home message for this is what we were able to show. So the top is a quad cam view of a monkey. And this is even before we were able to do digital recording, this was all done on VHS. And the control monkey doesn't move very much, yet the limbic disturbance, what happens is this animal is developing what we call a stereotypy. And in this case, he's compulsively licking and biting his fingers. And if you do that procedure and let them run free in their cage, they'll often engage in picking at their hair in one spot. And that's often one of the symptoms of OCD in humans. It's called tricotillomania. And they just can't help but pull out their hairs and literally they Brazilian wax themselves at every place they can reach. Or usually it's one spot where they keep pulling. And it's recognized as a form of OCD. So the video has stopped. And so we're going to move on. And this is just to emphasize that limbic dysregulation causes obsessive compulsive like disorders. And that's critical for what we're going to try to understand for the Wuhan outbreak. And the people, the people doing this very bizarre behaviors of spitting and wiping stuff, licking stuff. And like I say, when we did these experiments and we did them in the open cage, not so much spitting, but definitely licking of bars would take place. Licking and biting of his fingernails because he can't reach, he can't reach anything right there because his head is fixed. But the the licking and biting is a distinct feature. I've seen it in Tourette's and one of the more unusual cases that I saw a few years ago was a young boy who just couldn't walk past the car without having to lick the mirror of the car. And, you know, it's one of the more absurd, not absurd, it's one of the quirky behaviors that people with Tourette's or OCD can display.

And so the OCD is quite often a recognizable behavior. So another one is handwashing, right? People compulsively handwash. And I guess the yes, that's right, Bruce. Absolutely correct. And like I say, if people want to keep adding in the chat, I don't mind. I'll keep looking at it, see if there's questions. Like I say, handwashing becomes an obsessive thing. Checking locks, anything could become an obsession and you'll do that behavior. It might be a normal behavior, but the amplitude and quantity with which you do it each time will differentiate you from being a normal individual to someone displaying the disorder. So we've established here the disruption to limbic regions can induce stereotypy, obsessive compulsive behaviors.

We should see, so here you're going to see the disinhibition of motor tics like we saw with the young girl at the beginning. So this is a normal monkey. He's just pressing a button for a reward. Okay. And they'll happily do that for a thousand, two thousand trials to drink three, four hundred milliliters of water. So now he's being disinhibited. You can look at his arm and he displays an arm tick. So look at this one. Okay. And he wants to press the button, but he's, he's got a tick now. Okay. And, oh yeah, there's no soundtrack with this, so I can just keep talking. So the, we can stop there. I think we don't need to see those. So in terms of publications, because they often, they, you build a series and you build a body of work. So having established the neural network properties in the cortex and basal ganglia, that was done as part of my postdoc in Bar-Ilan University in Tel Aviv.

And also postdoc, Riken, this global dysrhythmia of cerebro-basal ganglia, cerebellar networks underlies those ticks that we were just looking at. And what we're going to do right now is we're going to learn how the brain looks or the brain state changes from a non-movement state to an abnormal state and how it relates to the physiology at either end of the system. So what you are looking at here, so if you, I'm going to jump back to slides just to give you guys some sort of insight to what we're looking at here. So what you're now going to look at is recordings made by this device that have lowered electrodes into the brain and are recording from around the site where we put the injection. And in this case, it's in a part of the striatum called the putamen, the sensory motor putamen. And you're going to look at all the signals that are recorded simultaneously from this channel and also from this one. Okay?

So let's go back to our electrophysiological data. And what you're looking at here is something called a local field potential. It's not neuronal spiking. It's kind of like the sum of all the electrical or ionic activity relative to your reference and ground that you're recording where that electrode is. The top trace is recorded from exactly where the injection site took place. And then there's a recording from nearby a couple of millimetres away in the target region. Then you can see the next stage is the GP, the pallidum is segregated by a bundle of fibres called the intermedullary lamina, I think it's called. I should know that, but it's been a long time since I used it. So the GPi, this is the output nuclei of the basal ganglia, remember. And then you see these spikes emerge in both the motor cortex and the cerebellar cortex. And then you see the burst of muscle activity. Okay. Now, one of the interesting things from my perspective, I don't know if there are other brain geeks watching this, but you can have this type of firing or dysrhythmia occur and it not propagate to the output regions, cerebellar or the cortex. And so even though the same patterns occurred where these grey highlights are, you see no tick. And that's going to be more that you need to keep this in mind for the later parts where we look at the vocalisations and the thing that Tourette's is really famous for, which is something called coprolalia, where you're talking to a Tourette's patient and suddenly in mid flow, they'll say something really inappropriate like fuck or pick whatever swear word you cunt, you know, it goes like that. And you often hear very visceral sounding expletives and they don't mean to, it's just part of the nature of the condition. The figure to the right we can ignore. Let's move on. These are the raw neuronal tracings. I'm sorry the order is a little bit flipped out, but these are spikes. So individual neurons that are spiking. So this is the EMG across the top. And in this case, it's motor cortex here. And what I want you to sort of take note of is the firing which pauses at this point and then the midway point of this event, the motor cortex bursts and that would be the jerk movement of the arm. And here you can see the same response. In this case, there isn't the response in the cortex. And basically cortex has transitioned. If you put recording electrodes into the cortex, you generally hear a sort of spontaneous ongoing activity. But what appears to happen is you reach this bistable state where you see the firing, you burst for the tick. It then goes quiescent and then it bursts again, quiescent and burst. And it's a very distinctive neurophysiological pattern. We're not saying that's exactly what happens in the brain with Tourette's. It's just a model and it's a way to sort of test ideas and theories and therapies. And in my case, it was testing the idea that deep brain stimulation targeted to specific regions in the basal ganglia would be an effective therapy for intractable Tourette's. And in some patients, it can get very, very bad. So let's move on. So we've done the firing. This is a lot to do with timing and physiologists and scientists are all want to see firing before an event to imply causality. And that's what this slide does. We don't have to dwell on it. If people want to look at it, I'll put it up on. It's up on research gate. You just type my name at Google research gate and my name and it'll come up and you should be able to get all these papers to you. So if you want to look at them, this is just more timing, but it's probably easier and quicker just to establish that basically the brown, purple and green are all nuclei in the *basal-ganglia:basal ganglia). They're firing up to a hundred, a hundred and fifty milliseconds prior to the firing you see in the cortex, but also the cerebellar cortex and the dentate all have similar firing patterns. From a neuroscience perspective, what that means is what I talked about earlier, where the synaptic distance is the same between the output of the basal ganglia and its target areas, which are involved in disinhibition of behavior and conducting controlled behavior like taking a drink. So cheers everyone. It's just tea, but I need a break. I don't know what we've been going a long time already and we're just really getting into the meat and potatoes of it. So yeah, I don't want the audience to get too bored, but basically this is the neural activity sort of slowed down ten times and striatum, GPe, GPi, motor cortex here, cerebellar cortex and muscular activity here. And you can sort of see the tick generating sequence propagate. There it goes like that and you can just watch. And if you watch it enough times, you can guess what's when the tick is going to come and when the muscle activity comes active. And there you go. That was another tick event. So people who are interested can go back and watch that and try to sort of imagine what the networks are doing. So let's move on. Let's not dwell on that. So one of the criticisms and your scientific work is always, always going to get some criticism from someone. Bruce, I'm glad you're enjoying it. Thank you very much. And one of the things that I always get with reviewers is, well, in order to because we put, or I tried to say that this is a model of Tourette's and Tourette like disorders in order for you to go to your clinician and the clinician to give you a distinct diagnosis of Tourette syndrome for one year, you must have a combined muscular tick like the arm, but you also must have a vocal tick. That's the classic medical dictionary definition of what Tourette's is. Okay. So, and it was a problem that we couldn't see or hear. Yeah, you see and hear vocalization or ticks. But there had been previous work that said they'd seen some vocalization by disinhibiting anterior cingulate. So by chance just poking around in the nucleus accumbens, this is the region that we're interested in that involved with the OCD. We see vocal ticks. If we do exactly the same procedure as we did in the sensory motor, we just do it in the nucleus accumbens. So it's limbic versus sensory motor territories. And the only difference being location and you get a much different symptom profile and disinhibiting the nucleus accumbens gives us vocal ticks. And this was a, I don't want to be bragging or something, but this was a highlight in the field to be able to sort of track in real time the neurophysiology and also the metabolic activity because we were able to do PET imaging. So as well as biosafety lab training, I've also got training in how to work around radioactive environments. These are all the joys of research and trust me, they're boring, boring, boring things to go to. And there's probably too much of it now because universities and institutes are sort of instruments for soaking up government money and also becoming worker farms. And you can only have so many researchers and lab space. So then they expand the bureaucratic side of the institute. These often get out of control and then spoil the fun for everyone. So again, I'm digressing. So let's get to what's the neural mechanism of vocal ticks. So again, what I was just talking about, so here the injection is targeting the nucleus accumbens. This is going to give us the vocal ticks. This is a sort of outline diagram that you would see from any atlas. This is derived from histological sections taken from the monkey. So you slice through the tissue, you mount it and then you can trace around and you can see where the injection sites are. And these are the sites where we would induce the arm and facial ticks, but no vocal ticks.

So let's move on. All right. So let me, I'm going to need to turn off my laser pen and you're going to hear a vocal tick now. I hope if it doesn't mess up. And there's the vocal tick ending and lower the volume right now. So, you know, that's quite a sort of, in neuroscience terms, that was a big find to find this reaction and the way that it worked and for it to be so compelling and obvious because usually a macaque is a, if you bring him out and into the box, he's pretty silent. You might get the odd coo or grunt, but nothing approaching what you've just seen. Just in case, thank you very much. You did not hear the vocal tick. Really? I'll try again. Oh, I know maybe what's wrong. Wait a second. Yeah. Okay. I'm going to fix it now and play the vocal ticks. This should grunt, but nothing, nothing approaching what you've just seen. Just in case. Thank you very much. You did not hear the vocal tick. Really? I'll try again. Oh, I know maybe what's wrong. Wait a second. Okay. I'm going to fix it now and play the vocal ticks. This should grunt, but nothing, nothing approaching what you've just seen. Just in case. Thank you very much. Really? I'll try again. Oh, I know maybe what's wrong. That's an awkward place on which to stop, but I'm hoping that you guys could hear ticks. So if I could get a signal, a thumbs up that you did hear something. Okay. So you heard it right now.

Now the next thing that I'm going to show you is these limbic regions are, they're tied into a lot of visceral. That's an awkward place on which to stop, but I'm hoping that you guys could hear ticks. So if I could get a, a thumbs up that you did hear something. So your assumption is correct. You are looking at a monkey penis and the monkey has an erection. Now the next thing that I'm going to show you is these limbic regions are, they're tied into a lot of these autonomic type functions. And so one of those being these abnormal sexual responses. And then I'd want you to think about how much of your time is often spent thinking about things of a sexual nature. And often people can then become obsessed about it. Same happens with love. All this sort of involves that circuitry. And here we're literally switching it on, on and off. There's no dignity for the monkey in this respect. But this is why

I'm showing this is that you guys need to understand that if COVID, if Corona Chan can get into your brain via the nasal mucosa, transfecting from the olfactory bulb into the limbic region, then there's no telling what it can do because all these functional regions are all overlapped across each other and through each other in this complex hyperdimensional space.

So you can read this. Okay. But it is a trigger warning. And Tyler Durden, so I'm a fan of Fight Club, says if you are easily offended by scenes of a sexual nature or scatological nature, look away now. And there's no telling what it can do because all these functional regions are all overlapped across each other and through each other in this complex hyperdimensional space. Oh, I missed my, my voice is audio looping. Right, because the output is, let me just fix that. Oh, I missed my, yeah, it should be ended right now. And everything should be good, good to go.

So yeah, as well as these vocalizations, you can induce these sexual responses, the big splat of brown is what you think it is underneath. So disinhibition is leading to those, those responses and try to imagine what someone with a similar disinhibition is going to have when likely they're also not feeling well and interacting with the public and interacting with society where society is now going to start clamping down on individuals. You know, you might think you've got your mask and what have you, but for sure, as the states of emergency kick in, people are going to get frustrated and that disinhibited state. So one thing I don't show here is the monkeys do get, you're killing me. All right, is that better? I'm hoping so. Yeah, I'm hoping it's better. Diarrhea and erections, yeah, just okay today. And a whole bunch more aggressive behaviors, all sorts of weirdness.

And in 20 years of research, one of the things that we found was that that region is acutely sensitive in a way that the sensory motor regions are not. And that was just a sudden death syndrome. So you would give the injection and then one second you've gotten a live monkey and the next they're just dead and they sort of die within 30 seconds. There's no lesion in the brain. There's no bleeding in the brain. We know that the brain handles probes relatively well. Thank you that the audio is better. Praise be to Allah and the good Lord. Let's keep this thing rolling.

So like I say, there was this degree of lethality to aggravating this region and the only workable hypothesis that I'm even able to come up with is it's virtually impossible to test, you know, the cost for a monkey in a research institute, you know, in the US, $20,000 probably, maybe not that much, but a big ballpark figure around that. So your and the ethical concerns with primate research are such that you can't just keep having dead monkeys, right? But in the case of nucleus accumbens injections, a few times we've lost animals, a few times other animals. I don't want to implicate too much my other researchers with what is this endeavor. This endeavor is literal career suicide for me. But you sometimes you just got to do it, especially when you're just sort of seeing such terrible negligent behavior from people like the who it's all corrupt.

They're all just grifting for money. And right now they're hoarding supplies so you can't have them to their own people can have them. And in my mind, you pay their salary. So you've got just as much right as they do to this equipment. It should be it should be this should be a more equitable way of doing stuff and not shafting people, especially with it arriving on the west coast of the US. You know, there is a lot of people that do live homeless. You know, those people need looking after too, because they become spreaders.

And you know, it's a it should be a wake up call for everyone that we need to sort of clean up our act with respect to how we interact with each other. And yeah, I'm sort of digressing again and bringing opinion and my own thoughts to another matter. So let's stick with the science.

So let's go on to our next next slide. And, okay, so this is from this is called positronic… positron electron transmission {positron emission tomography}, which is for PET imaging. So here, the animal gets a IV cannula put in, there's a massive cyclotron, it basically destabilizes the water, it becomes ¹⁵O labeled water H₂O. And it's pulsed into the animal in sort of two minute window. So the… it's given IV, the PET is looking for a change in in this two minute period. And then all those two minute periods are stacked on top of each other. And you get something approximating where neural activity is active.

And what you can see, so the top one… no, let's start with the bottom one, which is motor. So PET activity, which is a measure of the metabolic activity, we can see is restricted to the motor cortices, and also the contralateral cerebellum. Okay, so we've got electrophysiological data, and now physiological data in real time that we can lay out over each other. And that says that we're now hyperconfident in what's happening in the circuit and how the brain is responding. Now, a few years ago, if you'd asked me the what would I what would I how would I encapsulate my thoughts with respect to the mechanism of tick generation? Few years ago, four or five years ago, I would have said, we know what is going on with respect to the physiology and the metabolics.

And we can predict down to the millisecond, depending on where we're recording in the brain, how the brain is going to respond. So that's what we're going to look at in the next slide. However, when you induce effects, so that this one is the limbic region. So here you can see we get activation bilaterally within the anterior cingulate cortex, so both hemispheres. That's illustrated here and here. We also see activity bilaterally in the hippocampus and the amygdala. Okay, and hippocampus and amygdala. So hippocampus is very much involved with memory. It's a well studied structure in neuroscience. And literally, you know, they can follow these cells as a rat will learn the intricacies of a maze and it begins to learn marker signals around the experimental setup. And the amygdala, this inhibition of amygdala induces what is could be described as a fear or anxiety state. So when you walking down the road late at night, and you hear a big growl behind you, that might be a tiger or a wolf or a pack of rabid dogs, pick your bear, maybe anything, pick your animal doesn't matter. That feeling of dread and fear, that comes from the amygdala. So the vocal tick limbic response is activating. And actually, the very important thing is it happens across both hemispheres, which is absent from the sensory motor networks. The sensory motor networks are highly conserved. They're conserved across species from lower vertebrates up to higher vertebrates, such as man. And like I say, we can get a very good breakdown of what's doing what. And so the implication of not only the nucleus accumbens, but also these deeper structures with involved in memory and fear conditioning adds just another level of complexity that could potentially happen if COVID is transfected through the nose into these structures, okay?

I'm not saying it's going to happen. I'm saying that there needs to be an understanding that it might be a potential if it can kill cells in your brain stem and stop you breathing, if for sure can go into these networks and mess around with them. That would be my conjecture.

And we will carry on exploring. And so as the keen physiologist among you will have noticed in this next slide, what we see is the... So this is the grunt that the animal made. So like that. And then you're looking at the anterior cingulate cortex and recording in the nucleus accumbens. Okay. Now, remember I said that it was possible to see responses in the basal ganglia, but the cortex and the cerebellum would not respond. However, very unusual responses started to be seen with the limbic responses where there would be no activity, nothing that we would recognize as the tick generating signal, but we would get a vocalization. And there's one here, there's one here, here, wherever there's a gray stripe, there's no noticeable signal propagating across the network, but the animal still grunts. So that kind of indicates that it's an emergent state that the animal is in. And I'm guessing, you know, there is this degree of anxiety with the tick for sure. I mean, you don't want to anthropomorphize your subject too much and say what you're thinking about it, but, you know, truth be told, it's not a pleasant experience for those... They're little heroes in my mind and they're frontline soldiers. And just at the bottom, you can, this is there just to exemplify how close the relationship is between motor cortex and the emergence of ticks.

So motor ticks, we can get this very tight precision. With vocal ticks, it's more about the state and in that state, the animal will, the subject will engage in behavior like licking, like spitting, like swearing, like engaging in violence. The inhibition levels are lowered and the consequences of that are unpredictable, I would argue. And if COVID, even if there's a 1% chance that it could do that, 1% of 100,000 people going nuts every, by the hour, is that a sign of Tourette's? The behavior or the physiology? Tourette's is, I mean, it's a clinical diagnosis and it's diagnosed usually by symptoms and the symptoms are you need a persistent motor tick and you must also have a vocal tick concurrent over a 12-month period. If you have that, that gives you the diagnosis of Tourette's. What's happening in the brain up until this research was started and I was there at the beginning and being through hell and high water to keep doing this research because actually I've been lucky to miss the scramble for the greasy pole and the funding because I always had facilities in which to work and I always managed to scrounge enough rescue equipment and through American philanthropy and a specific charity, I was able to cover my living expenses previously and enough to get 20 years worth of research and enough to suddenly get the word out, I hope. So Bruce, in the humans, we literally don't have neural signals from ticks. There's some work coming out now because of implantation of the DBS probes but we don't know for sure if there's a one-to-one match with the ticks. My working feeling is that it's not going to be like that. The manipulations we make to the network is in extremis, meaning we take it to its absolute limits and if you go beyond that, then unwanted consequences occur, namely the loss of your animal, either fruit or I think what is autonomic collapse.

So like I say, the states induced by mucking around with the, for lack of scientific term, but manipulating, that's the word I was looking for, manipulating limbic networks even when there's not a signal, once those networks have been activated and the animal is in that state, you need both for a proper diagnosis. But look, there are people with just ticks that get diagnosed with Tourette's as well. It comes down to the clinician and the criteria for the vocal and muscular tick is often discussed and I was at a meeting in April, I used the last of my funding to go and ask them to release funding to me and I can't get it because I'm not right now affiliated with an institute, I'm doing this off my own back and now I've done this, no institute will touch me with a ten-foot pole, that much I'm sure of. You don't give the ungarnished truth to the masses and not expect repercussions, especially when you're showing primate research, but that's my cross to bear, it's my decision to do it and I'm doing it because of the, like I say, the negligence, the real negligence of these institutes and these people who are messing with our systems that, you know, our forefathers put there.

I don't want this panic phase of the outbreak to cause more, potentially more harm than it can. So if we can get this message out to people that says, please, you know, you can survive for 30 days, 60 days, let this first spasm get by and then hopefully supply chains will kick back in and we're not merrily going into Mad Max. Well for me there were three original Mad Max, I can't, I can't go with the new one, it was a horror show of woke cinema and I don't want to go into a Mad Max 4 scenario, how does that sound?

Okay, so we've still got 19 watching and I don't know how, we've been going two hours, so props to you guys for hanging in. You know, we're getting, we've gone past halfway and we will try to sum it up actually.

So the next slide is just, these are called perievent histograms, so this one is for the myoclonic ticks aligned to, the reference is the LFP spike at the injection site and you can see that the activity is shifted to the right and it takes, well, you know, approximately 50 to 100 milliseconds for the event to occur, the muscle contraction is around 200 milliseconds. However, when we look at vocal ticks, we see a sort of bimodal distribution around the event, it's not, it's not so, so physically locked to the underlying pathology and like I say, we're, we can only really second guess what the monkey is, but my argument is, is it's the state, the overall state of the animal that's important, just to explain the axes, this makes sense, this one is in microvolts, this one is the reference events, so basically we're looking at around 4,000 individual muscle ticks all stacked on top of each other and also around 3,000 vocal ticks, so the database is quite, quite large and so we can be quite confident in the statistics that we're putting out, unlike those sneaky Chinese, no, I take that back, there are some good researchers there and some really try to get the work out or get their opinions out about what COVID and Wu Flu, Corona Chan, whatever you want to call it, what was his name, Wen Lee Chen, I want to say, I need to look and we should, we should mention his name while we're doing this, doing this stream, Doctor who warned of COVID, dies, Wu Han, apologies for breaking up the flow, let's see, can we get his name from somewhere, come on, yeah, when you want something quickly, suddenly internet decides to go real slow, I apologise, dead air is never good, so I'll just keep bantering away while it's doing this and see if we can get something, but this, Li-Wenliang, I think is how you would pronounce it, Li Wenliang, yeah, so just to pull, let's get his face, so people remember his face, this is the guy that tried to raise the alarm about the disorder and sadly has passed away and part of this stream and me throwing my career into the fight and into public view, it's because of people like that that make sacrifices like that, there are good people in these systems, it's just the systems seem to be broken and of course there are broken people in the system as well, so let's, with that digression taken care of, let's focus back onto the science, let me just make sure I can see your comments, okay, yeah, look, maybe you're more than welcome.

Thank you for the compliment, if you can spread it out, spread this information out, let other people know and the more people understand the potential emergent behaviours that can come from transfecting the central nervous system through Covid, the better, yeah, that man was a true hero, absolutely and Bruce, here's a kicker for you for illness, so my lab was based in Daegu in South Korea, I was in Daegu in the end of November, December, I came back and over Christmas three weeks I had this fever flu type thing that I've never had before, it left me with dyspnea, where dyspnea is like you're sort of, you're struggling to get air all the time and basically in December, January he was making the warning and it was around that time I'd sort of got word of, you know, potential problems with a monkey lab over there and so I'm sort of heeding to that sort of thing but he literally from, maybe I can find that out as, he's working a fight against corona, he died at, doesn't say when he was breaking the news and you can find it, it's on the net and I want to say he gave us many, many weeks notice, okay, to get something done and put out to the world and yeah, so if I dedicate this talk to anyone it would be to Li Wenliang and I hope I'm pronouncing his name right.

Let's move on, and I actually think we're sort of working towards the end of, so we're looking at rasters and neurophysiological plots, this is motor cortex, this is the anterior cingulate cortex and now if you remember for the motor tic, the biphasic state was in the primary motor cortex, now it's in ACC so it's bursting but motor cortex is responding as well, it's got to because there's this element of motoric expression with the tic and you know, anyone that's sort of interested in physiology will sort of find this data sort of fascinating to look at, it's in my publications and you can read them.

If you have questions, it doesn't matter what you have a question with at any specific line, it's my job to answer those, so don't feel, there's no such thing as a stupid question, what's stupid is if you don't ask when you do have a question, so with that we'll progress too and actually I think we are coming towards the end.

So we're getting to the point of phase amplitude coupling, so we want to understand how the tic can emerge without there being an obvious physiological signal that we could so clearly detect in the motor system, we see it in the limbic system but it's the relationship and the causal relationship between the signals is broken and you can do a type of signal called phase amplitude coupling where you look for target low frequency activity and what you'll do is you'll try to line up and see where if there's a strong high frequency component lining up with any point on the sinusoid from like I said, it's basically you have to think of it as half a circle like that around and you're looking at the, if there's a correlation between the peak or the trough for high frequency activity, okay and I know it's a tricky thing to sort of get your head around but why am I showing you this, it's to show you that we were able to detect a signal in the limbic system that seemed representative of the agitated or not the agitated but the complex behaviours, the grunting, the sexual responses, the emotive responses like aggression, all those things, as a scientist you want to find some causality in the signal and of course there's always going to be some ambiguity, I know this, nothing is a hundred percent even in science, even with the best measurements, there's always something tiny that could potentially grow.

So what we're going to look at next, this is published data again and basically if we do spectrograms on and off ticks but basically the important take home is that there is power in the low frequency range during the vocal ticks and also in the, it's not quite so obvious in the periods between but if you do the analysis what you find is that there is, this is called phase-phase coupling, not phase-amplitude coupling, there's a subtle difference and if people are interested I can do a talk more about Parkinson's and phase-amplitude coupling but the take home of what this slide is, is to say that we were able to extract out a significant signal while there was that quiescent period and vocalisation would spontaneously occur and the dark red spot shows some interaction, some phase-phase coupling in the alpha frequency range and then there's this interesting pattern in the high beta range and the inverse, so this is between nucleus accumbens and anterior cingulate without LFP spike and this is between nucleus accumbens and motor cortex. So you can see there's like a sort of syncing source phase amplitude coupling across the cortical mantle and it's a signal we can pick out without there being the obvious tick signal that I'd been studying for nearly 20 years before that.

So that's the sort of target and one thing I wanted to show was, so the interhemispheric firing, so the brain is in two halves and when we look at the PET imaging what we see is we see activity bilateral to the response and what this plot is showing is a response aligned to the LFP signal at the injection site in one hemisphere and the detection of spikes in the other hemisphere and the peak is around 25 milliseconds.

Now those that are into ideas of quantum consciousness and all these more metaphysical, the more nebulous components to behaviour where we make presumptions about consciousness, one of the really famous models is the Hameroff orchestrated, what's the O, objective reduction, orchestrated objective orchestrated reduction, I need to, that's shameful, I don't know that, let me just check that Orch OR model, Orc OR theory, this is Hameroff is the anaesthetologist and it's called orchestrated objective reduction which says that there's a, the microtubulin structures within neurons are able to engage in quantum superposition temperatures that even a few years ago people would have said were impossible but literally data is coming out by the day and week where people are showing that microtubulin does have these properties so within the boundary condition of a cell you know subatomically one side of a cell to another is massive distance so if you can, if there's some way that they can be instantaneously communicating that's a big deal and I have a lot of ideas myself about how this is transmitted otherwise and full consciousness requires both hemispheres and the orchestrated objective reduction model has a theoretical time constraint to it where the process of consciousness is sort of propagated a long time. I hope I'm not butchering this too much.

The point being that us finding this 25 millisecond window between the two hemispheres in my mind is a good foundation for saying ah now we can see fingerprints of that response in the brain it's very difficult to do it intracellularly and if we can see this 25 millisecond propagation this opens up a whole new world of possibilities with respect to neuroscience and…

The next slide is a movie and it doesn't require sound and what you're going to see is you're going to see so this is less to do with COVID this is here just for scientific interest because people do contact me about Tourette's and putting these videos online for public consumption I'll get some more and this is an experimental trial for nucleus accumbens deep brain stimulation so in deep brain stimulation essentially get like a pacemaker and they'll implant it here under the clavicle because there's a space there they'll tunnel leads up inside the tissue of your neck they'll come out they'll connect to leads where the stimulating probe goes into the brain and then they can do high frequency around 150 hertz and that tends to ameliorate symptoms both in hyperkinetic states like Tourette's but also the other end of the spectrum Parkinson's disease deep brain stimulation is becoming the gold standard treatment so we're going to have a look at that…

“Nicotine stops the cytokine storm”, look I can't answer to that and I'd like to see that tested I mean great if it does if that's the reference I'll be happy to look at it but yeah anything that sort of can inhibit that cytokine storm is a good thing to have I will be going out and buying some nicotine gum tomorrow well I'll smoke a cigarette the cigarettes still dirt cheap in Japan we're not allowed we're not allowed vaping here it's prohibited because the tradition is that the smoking companies have got a the ear of the government and they don't want these products coming in and actually with supply routes shutting down the factory of the world basically shut down everyone who got into vaping is probably going to have to go back to good old-fashioned cigarettes lung cancer and COPD it's terrible it's what took my father away from us he was still relatively young 69 he fought with that condition for 10 years bless him and I wish he had access to vaping before before but I'm digressing it's it's not it's my issue not not the audience’s.

So let's have a look at this therapy in action so I'm hoping this should play normally yes okay so what am I what do you what do you need to look at so let's look in this panel okay and we're gonna watch 60 seconds one minute of this animal doing this task okay and this this animal is thirsty so the only time they get fluids is when you're doing the experimentation and the animal is button pressing for and he's highly motivated for the the reward of the water so his fixation is water water water he knows if it lights up water comes on he has to press the button and literally they'll do that thousands of times per session so now we're seeing we're coming up to when DBS will come on so circled here it says DBS off that will turn red when the DBS comes on and it's on for 30 seconds we're coming up to the minute it's going on now so now the monkey just stops his behavior okay I mean and actually he's relatively normal his eyes are normal he's looking around he's still sort of licking and doing stuff but it's interrupted the flow state of the animal and we're we're engaging in the disruption of motivational behavior where you're doing this fundamental thing of making a choice it's now gone off okay and now see he starts the task again okay and we can sit there's about five minutes of this we can sit and watch it for a couple of minutes it's quite a sort of repeatable result I've been in clinics where they're using it successfully would I recommend deep brain stimulation for someone with Tourette's who has a child no I wouldn't it would have to be really intractable case in a young person where they're causing injury to themselves through the tick okay so oh

We've crashed? oh it stopped never mind we've got the idea right that the the DBS did that I'm just hoping the computer is still working and we're still streaming okay we're working.

So okay so this is just the raw the raw data for that response and I'm actually seeing that this is the end so anyone that sort of is still here the 20 heroes that you all are that sat and listened to me for I don't know two and a half hours a bit more with very sort of deep theory and science and you know I did go a bit technical and long-winded but I wanted to give a reason the specific reason that I did this was to try to explain the abnormalities in behavior that potentially occur around covid infections and look there's a scenario that was running through my mind it could just be that a lot of people are asymptomatic okay and they get they get transfected into the CNS and the it manipulates their behavior into becoming less controlled under certain circumstances and then they it's those people who might just pass on the next generation a virus doesn't want to kill its host it wants to keep replicating for as long as possible and a weaponized or research strain that got loose probably isn't designed to sort of have a 80 percent morbidity rate it's designed to bring down society's infrastructure and induce panic and inducing panic in the United States I think is gonna have potentially way worse consequences than in Asia in Asia they haven't been panic buying to the degree they have you know you can see going on in the western world but the western world is you know they've bought wholesale into the idea of me first once I'm done then we can look after you and under these sort of circumstances we need to sort of rein that in a little bit I think a good example right now the Japanese government have been highly negligent but the Japanese people have been a model to behold the same with the South Koreans and I would say the South Koreans have been even better and that's simply because that their system is geared for mass casualty events in response to conflict with the north okay and so that's why they've done such a good job detected so many cases and they probably have good research unpublished research because it would involve biological weapons but you know they've been doing therapies like IV massive amounts of IV vitamin C and other molecules drugs whatever you whatever they think gonna work and you know I would think that these statistics are clear coming from Korea I don't trust Japan's I think they're hiding a lot because of Olympics excuse me final thoughts that the fact that all so many of the higher-ups in Israel not Israel Iran have taken have been infected and China being crippled to me suggests it's not the result of a natural zoonosis this is done with intention the intention is to cause chaos and someone or something an entity whatever you want to call it has set this thing out into the environment and now everyone's gonna have to deal with it fingers are gonna start pointing and the…

The Middle East is just a good example of how chaotic things could get and I could imagine the US where some people think their rights are gonna be infringed has the potential to swing in directions that I would hate to see it go and the world as a whole no matter their feelings probably I'll choose my words carefully here would in the case of a reduction in the ability of the United States to project power are likely to come under the purview of other entities that are probably less benign I know I said that in a long-winded way but I wanted to encapsulate everything that I was saying.

And we have with that reached the final final slide which is me just again giving my oh come on PowerPoint behave oh so here's just my contact information again I'm not I think ebegging can be somewhat of an irritation I know it happens every YouTube video but I'm at the be it's a self-inflicted head injury self-inflicted accident but I was it was on my watch I'm doing DIY and I had a TBI so my working my official working has been not so good since 2016 when I had the head injury it's much better now but I stay home with the kids which is actually awesome I highly recommend it and my wife has to do the supporting she quite ironically considering the CEOs response in the last few weeks Jeff Bezos where he's liquidated his stocks or a lot of his stocks he's told his workers to stay at home but the peace workers the temps who were running through your fulfillment centers are paid by the hour and they are it's a real tough job a real tough job so I do have PayPal and there's no obligation just yeah

Just if you find this useful please pass it around it's important that we get the get the fear under control the way you get fear under control is by being aware of what's happening and understanding it also understanding that the organizations that are currently supposed to be looking out for you don't have your best interests at heart any kind of covering for your mouth and nose is better than nothing and what I would recommend is you get saline solution and…

”If I'm seeing this correctly nature found a way from Chinese biowarfare screw-up”, I think it's a bit more complex than that you know I sort of toyed with the idea that it was a Chinese first strike literally inflicting it upon themselves and they're prepared to lose a billion half a billion people right and they wouldn't flinch and my thoughts were maybe they were trying to do that to trans… get the infection going worldwide so everyone everyone gets into a panic and collapse and the in that chaos where America would be forced to withdraw its overseas troops to maintain law and order in the United States and in the United States there are lots and lots of people who don't like the federal system right now and a constitutionalist and would be happy for another revolution I just hope that revolution is a peaceful one and one where that second amendment isn't used by its citizens that's what I'm trying to do this for if we can keep the US calm keep your friends calm keep your family calm understand the potentials of it that it's not just it has the potential to not just be a knockdown pneumonia it has the potential to transfect your nervous system it transfects your nervous system it can blow out the amygdala breathing regulatory network so you can't you have to consciously control your breathing quite a feat that you that it would induce and we don't know how much that repairs and I've just gone through that it the paper which I introduced at the beginning their worry is the infection through the nasal olfactory bulb from olfactory bulb into limbic networks is one synapse and as we've seen in this talk manipulating one synapse has very very profound effects on the individual and you probably don't want to be near someone who is in that state they're highly unpredictable and the chances for catching something is high I would guess.

So I think I've sort of finished my spiel I don't see I'll have a look at some questions I'll bring them on to my if I can look at them now so let me just go through the so Bruce says thank you for the presentation I learned a lot COVID may present as uninhibited antisocial behavior speech etc similar yeah that's what I'm saying that once you mess with that limbic circuitry it just ties into so many things that yeah it's until we know otherwise be prepared for spitters lickers and fighters slappers that Chinese guy was slapping the the the garage service so she was cashier so yeah we can expect all sorts of maybe maybe I'm just putting this out there because I don't think that information has been forthcoming from these officials I think they know a lot more than they're letting on and I'm literally putting my reputation and name on the line by calling them out and I would ask your help in doing that but again let's western world has become so lucky for 70 years as a whole we are soft to hardship absolutely soft times make soft men and hard times make and that leads to hard times and then hard times make hard men and we probably need to balance it out a bit more I'm seeing this correctly yeah we answered that one from Mick I hope I answered it enough for you but my opinion is from watching it from an early level probably way before many people were I had the suspicion that it was a weaponized or not just weaponized weaponized or research modulated essentially are the same thing they're interchangeable so it could have just been research done and they're trying to up regulate or down regulate parts of the genome and proteanomic sequence to get a better understanding of what it does and then my thoughts were they've gone and tested it in primates in a BSL for facility someone has taken a bite or a scratch it happens a lot if you work with monkeys and if that happens it's a massive massive pain in the ass because everything has to stop you have to get checked out and in a BSL for laboratory if that happened there would be specific literally dead man switches multiples to stop that person getting out if they did the right thing by saying hey I got a little bite or scratch and it exposed something or maybe wasn't even that light enough to sort of the cleaning of taking off the gloves wasn't done correctly or inefficient washing to get out the place hungry you need to get home any sort of thing that could disrupt what is a highly controlled environment there's multiple sources it could also be outside entity targeting them and Iran we can all make assumptions as to who that could be and there's no need for me to go into that in this talk I don't mind doing that another time and I'm happy to discuss through that as well so I hope that's Mick answered you're more than welcome Mick hope that insights helped have we seen any Chinese troops infected or affected I think that that information is going to be kept very very hush hush we do know medical staff are being affected we do know important people are being affected as Iran the we'd never know that's I can't add anything more than that I would just be I'd be guessing as much as you were and what I would be sure of is these protocols involve specific implementations of martial law and when you're dealing you're not dealing with the old Yankee Joe and the good old British Tommy from First World War or Second World War where you know there was a reluctance or the the the kill ratio per amount of ammo fired was highly disparate compared to a modern trained infantry who are trained to so I discussed this on Blazing Press podcast earlier today though in this situation when that when the military starts protecting and patrolling those people are not your friends okay my advice would be to stay in bug in if they catch you out you know they've got strict procedures on what to do and you don't want to go where they would want to take you is how I would sum that up so let's see there's also a media story that we have so much look maybe look there's not just there's not just research scientists there there's a whole infrastructure of people there to maintain the facility and someone's for I can get there and get the monkey out what else would they be working on so they might have host animals that have that they're natural hosts for any pathogen so like the bat is a natural host for the Corona Chan Covid pathogen and so I don't know were they selling bats maybe.

I don't know I'll be guessing my guess is it's more a it's either some sort of accident within the facility that wasn't reported properly or someone has deliberately infected outside the facility and done something which well it's not I don't think I don't feel it's my place to sort of lay the sort of judgment on him that I would think he's deserving he's he's literally with God's hands right now he them she I don't know literally his you know an interesting fact is the the Daegu death not death cult but Christian cult {Sincheonji Church of Jesus} where they had this sort of I'm trying to think of the American versions of David Koresh the David Koresh type fella who was saying he was I broke my oh yeah just the Daegu issue with the breakout happening there there was a church of their sect in Wuhan churches and religious thing Kim Adams maybe potentially look if if if it's aerosolized or carried on droplets and they drop on rodents the Rastaman heavens gate yet that's another one I don't remember the the leader though and I'm wearing a mask I'm at UC Davis hospital with my sister the hospital had a CV case and yet none of the staff is wearing a mask right because the the surgeon general said it doesn't matter scientific papers say otherwise Asia says otherwise part of my channel is just a when I'm not talking it's just looking down into the the little valley where I live and people walk by every day and you just watch how many people are wearing masks okay there are 90% of them will be wearing masks yeah Bruce I think that's for sure and the Rastaman is right with the Chinese will lose half a billion and not blink and you know their numbers dwarf us if we want to play that game but this is next-generation warfare and doing this is part of that so we can mitigate their numbers through these type of quick reaction networks that I'm trying to sort of instigate here the so Bruce Wayne is saying it's deliberate bioweapon yeah look if they've engineered it for sure they can stick in a little sequence that exposes some part of the the structure the the the structure that conforms to the most stable state when it's in a fluid medium most probably there's probably some inbuilt attack point that a vaccine could could latch on to if it's been studied and worked with to the extent that would be a well understood bioweapon you know the same like we understand the consequences of VX nerve gas, sarin those kind of things we have a very very well researched well defined and well uh instantiated set of rules for how to work with those chemicals so for the biologicals you have to presume the same if they've if the entity that released this thinks that they've got a handle on this strain I would argue well it's already mutating into different strains and the vaccine might not work.

And the other question is are you prepared to line up and be the first one to test an experimental vaccine? I'm not going to be and look a thing that just shows you how demented this whole situation has got is the US gave China a antiviral drug called I think Renfineer {Remdesivir?} something like that and the US are just now establishing a patent on the on the on the molecule the drug and they gave it to the Chinese and what did the Chinese do they try to argue for that they want to patent the molecule so you're gonna have all these back and forth between people and yeah it's a it's a complete snafu and we are jumping into clown world I see a lot of questions coming in indiscriminate population reduction and the resultant chaos so who benefits what's obviously benefits the the people that took out the um who quit the CEOs who quit okay and liquidated weeks and months before where have they gone right all those billionaires all that uh the oligarchs that have uh vested the interest in sort of maintaining control and maintaining uh the the infrastructure that they have because they like their iPhones too and they like you know going to holidays have people serve them there's only so much robots can do right so they'll try and keep a few rounders uh cattle and like I say when they're lying to you like they have done I don't want to be overly dramatic or cause panic it's just the the outright standing up there is and saying stuff that you know not to be true in it vexes me deeply and…

I… I can't say I'm surprised because I work within the field and I know these people very well I know the character type and look I would even call out the surgeon general and that individual who is uh I forgot his name Joshua Joshua Adams is that his name but he's literally the same age as me right that's not surgeon general position age he hasn't published I checked his uh biography he hasn't posted uh published a huge body of work um

I'm sure there are many many people who are way more qualified to speak to this um outbreak and um again I'm I'm putting my reputation on the line by calling them out and saying that they're not being forthcoming with the truth they're literally requisitioning all the um all the equipment for themselves and then my other advice is look the cities hospitals are probably not the place to be if you get ill and you're getting the uh signs of a severe flu what I would do is I would say treat it like a severe flu lots of vitamins uh lots of fluids um if you've got uh fluid build up on the lungs don't lay on your back you can lay on your side best is if you can lay on your front your head hanging over the edge of the bed try to raise your chest and legs up so there's a sort of natural drain for the fluid uh decongestants all those types of things you can do so my list of medications was uh and americans are lucky you can go buy big tubs that can last you months at time you go and get acetaminophen by itself acetaminophen with diphenyl hydrolamine which is the antihistamine and is the uh tylenol pm or get ibuprofen aspirin vitamins um other antihistamines that are non-drowsy things like zyrtec uh anxiolytics if you can get them if you're a bit if you're getting anxious um and the prayer isn't working and it is looking a bit nuts outside they might just help or they might just help calm down your children what else would I try and get on that list uh you know if you're a nurse or you're comfortable with getting an IV in um you can make up salt and sugar solutions and um you know get them into someone if you have to it's just it's just a needle it's just a piece of tubing and it's just fluid if you're if you're in that bad a state and the hospitals are overloaded there's there's only so many icu beds that they can put in that um can give you the type of treatment that they think they want to give you so if the pre-Bötzinger complex is wiped out they have to intubate you intubation means intensive care unit it means uh uh giving anesthesia giving steroids for anti-inflammatory responses and a whole bunch of other drugs and chemicals uh yeah benadryl is a good one um the all those cold and cough medicines i would have them to hand um in that sign in the paper i just discussed they do say that perhaps steroid anti-inflammatory is not a good idea because that's going to inhibit the immune response in the brain so the brain has a bunch of cells microglia which sort of act like the brain's uh white blood cells and they sort of try to fill in uh damaged areas and uh try to in some way contain control and restore function um yeah if you can get an iv do a vitamin c drip bit salt sugar uh that would be about it for the iv unless you really have to do some sort of emergency at home um but then you're getting into complicated areas and i'm not a medical doctor i'm a research scientist in the neurosciences i specialize in disorders of the basal ganglia and neuropsychiatric disorders that's what i'm that's the point that i'm speaking from and the advice i'm giving towards about masks medications bugging in having food these are just sensible things that a lot of people are saying i'm just adding to that with the caveat that um i've worked with the level of people like the surgeon general and i know how those things play out in the meetings right now they want calm okay because if people get more stoked up uh the worse it's going to be and they'll say oh we have to get masks etc we need more food um go to war with the army you have right now, okay?

If you can get a bit more to you great but try to remember there's probably a young family coming behind you you know don't take don't don't i had this phrase if there was it don't steal all the nutella right so you know the mother coming behind sees that she gets jittery she takes all the strawberry jam etc etc and you know it sort of piles on and uh you need to avoid those situations would be my uh advice great my sister just had a brain tumor removed from her left robe she's on steroids for two weeks uh shena uh i pray that your sister's okay they do uh fantastic jobs right now in terms of contact that is your number one weapon that you have right now okay keep your kids from school don't listen to what they tell you with respect to they need x y or z keep them safe to you they're your responsibility don't go to work if you can avoid it work from home um if you're just doing a you know all work has dignity at some level um but if it's something you can do without uh for a month or two you can just kick it and look for another job or just come back if things have normalized in a month two months and didn't notice as long as you can sort of survive um i know these are sort of extreme personal things you can do but i'm trying to sort of mitigate the consequences of the people that have uh in the case of uh i'm sorry i need to check your name again uh who went to the hospital and they were never wearing masks who would who was that um i i can't remember.

Someone in the chat mentioned that they went to uh uc davis and not one of the staff is masked up that's a shocking state of affairs to be in um like i said i got ill uh over christmas after visiting Daigu in november and i had to go i went late at night i went to the er of chest pain and this is sort of ramped up after getting ill over Christmas and that's one of the things that people are talking about with this infection and the you know you can get pericarditis myocarditis you can attack the valves in your heart anything.

Once it's transfected into the nervous system and it can propagate who knows um and that's that's literally again i'll say it again that's why i'm uh trying to get this out to the public uh cheena it was you wearing a mask so uh good for you um to uh uh the the fortitude to uh it takes it takes a lot of uh mental strength to say i'm gonna be the first one that's doing something it's easy to do if everyone's wearing a mask around you but if you're out in a mask people are looking at you especially in the west in a sort of off hand manner and um you know there's social pressure to conform and with that conformity um really becomes it becomes problematic when people are trying to maintain what would be normal life and you're expected to go on trains and subways and buses and shop and all these things open you up to a potential infection and my advice would be in the advice from that paper that i covered that there was actually two papers covered uh from uh rapid it's a rapid report journal so they're peer reviewed and uh i think a journal of medical virology something like that impact factor of two not huge but um reasonable for the type of journal it is which is this rapid release so we saw two papers one which said um we can get transfection into the central nervous system and hit all these places we discussed and i showed the other is the uh the one showing mutation i didn't dwell on that but that's also uh same journal it was done it was published a week or two before what i will do is i will put the links below i haven't done that yet but i will do a lot of my day was spent uh talking with uh blaze tv and then trying to think what to do next and you know i i know that the first presentation i made was it was just for friends and uh people around me and for a bit of a laugh so uh that's my uh off duty side and if people find any bits of that uh upsetting or offensive um tough uh get on with it and you got bigger things to worry about um worry worry about what people are going to doing study this presentation and get everything in your mind straight and another thing to think about is if if the mortality rate is high so we've seen some estimates they could be as high as like seven percent right um that means people you know most likely are going to catch it and suffer some degree of trauma and you need like individuals need to prepare themselves for that uh trauma with respect to PTSD so actually uh one of the things i've found is that Tylenol after an event um can mitigate PTSD okay that's just one thing to think of um i mentioned uh uh

The soda uh soda water with the quinine in you know people need to just chill out think like british upper class uh in the colonial era in India they drink the gin and tonics because it keeps the malaria away they maintain a sort of active lifestyle but one where there are breaks and routines um i think we've thrown the pendulum too far there's way too much other all and methamphetamine type drugs being pumped in because people just want to work work work they want that cash and money and um that has serious consequences linked to it.

So I think it's coming up to quarter to three i'm gonna say uh sorry blazing press if it's a um miss xyz i do apologize it is late um i will say that uh speaking to robert i feel like um i found a pastor who could be my pastor what one i could speak to on a personal level he seems uh he seems a pretty based guy and um he's uh he's a rethinker and um you know if you're if you're inclined to want some sort of uh spiritual comfort in these times he's doing a great job that that's what i can say so uh robert uh uh blazing press yes i'll get it right and i hope to have more dialogue with him and i will say this uh if anyone wants to discuss on their podcast anything in this presentation i'm more than happy to do that i'll come on speak to your guests if you have a show um you could have 10 people and i'll try and fit it in um yeah he's very very patient and that comes from wisdom and wisdom comes from experience and i'm hoping i have enough wisdom to sort of get this through and um give some advice that's useful so yeah bruce wayne you're right sleep is the best medicine um after my head injury my sleep patterns are messed up i have to medicate for sleep now and i just accept that i do that um because i do yeah it literally helps with symptoms so uh miss xyz yeah look truth truth is um trying to get to the uh core of any issue right and the problem is is that complex phenomenon uh seem to engender structures to be built around them especially when there's something like uh money involved and um reputation and esteem all these things that sort of plug into ego are a detriment to sort of doing the science properly and the only reason i'm doing this in is because of the unique circumstances i'm under if i was sort of still fully employed in a pi position would i be doing what i'm doing right now i'd like to think i would but um perhaps not i don't know the difficult one to answer right it's like you know it's like the the mask wearing question right who's going to be the first one to wear the mask and who's going to be the first uh academic to stand up and say hang on we need to be doing this differently and i've seen enough to say now's the time to pay attention and we'll go from there so uh kim thank you very much so everyone in the chat that's been watching i'm gonna uh stop the streaming i'll put up the ip cams and stream them so you can look out onto the other side of the world from where you are and you can see that it's sunny the kids are playing it's not the end of the world okay so uh yeah final message is keep calm uh have faith and um just uh be cautious because there's wolves so i'm gonna hit the stop streaming thank you very much and i'll hopefully speak to some of you soon please contact me take care and god bless